Unit 4, Case Study 4 Skin Cancer

I have researched many different Web-cites and articles to try and determine what role genetics plays in skin cancer. Yes there are certain genetic mutations that are inherited, or passed through the germ-line, but the main cause of skin cancer is UV radiation which is an environmental genetic defect. Many cancers begin when one or more genes in a cell are mutated, creating an abnormal protein or no protein at all. The information provided by an abnormal protein is different from that of a normal protein, which can cause cells to multiply uncontrollably and become cancerous.CDKN2A- mutations in this regulator of cell division are the most common causes of inherited melanoma. They are however still very uncommon overall and can appear in non-inherited cases. People who have this often have a large number of irregularly shaped moles and are often diagnosed at a relatively young age. The MC1R gene provides instructions for making a protein called the melanocortin 1 receptor. The recepto r is primarily located on the surface of melanocytes, which are specialized cells that produce a pigment called melanin. Melanin is the substance that gives skin, hair and eyes their color.Melanocytes makes two forms of melanin, Eumelanin and Pheomelanin. The amounts of these two pigments help determine the hair color and skin usually the more Eumelanin the darker the hair and skin, also will tan easily. It also protects the skin from UV radiation in the sunlight. The more Pheomelanin the hair is red or blonde, freckles, and light skin that tans poorly, because it does not protect the skin. Which puts them at risk for skin cancer. Many changes in the MC1R gene increase the risk of developing skin cancer, including a common, serious form of skin cancer that begins in melomcytes.Skin damage caused by UV radiation from the sun is a major risk factor for developing melanoma and other forms of skin cancer. These gene mutations germ-lines are passed from parent to child through the MC1R g ene but UV radiation is the highest risk factor for getting skin cancer, and the most common in the most common in skin cancers. People who are genetically susceptible to skin cancer should avoid prolong exposure to the UV radiation from sun light, wear sun screen, and enough protective clothing when outside.

Comparative of the Great Gatsby, Casablanca and Translations Essay

The texts which I have studied in my comparative course are â€Å"The Great Gatsby† (G.G.) written by F. Scott Fitzgerald. â€Å"Casablanca† (C.B.) directed by Micheal Curtiz and â€Å"Translations† (T.) written by Brian Friel. The cultural context of all three texts impacts on how and why the people behave the way they do. In this essay I will examine the elements which I thought had the most significant impact on the characters which contributed to their behaviour throughout the narratives. The first aspect I will examine is the setting of all texts – how it impacts on the way in which the main characters act and the consequences it has on their behaviour. G.G. is set in the â€Å"Roaring Twenties† in America. Fitzgerald set G.G. in an altered version of Long Island and Manhattan where Great and Manhasset Neck became East and West Egg and the large landfill site at Flushing is renamed the ‘valley of ashes`. This glamorous decade of the 1920à ¢â‚¬â„¢s was one of great cultural, artistic and social developments. WWI had ended in 1918 and left people disillusioned. This generation that fought and survived were ‘the lost generation`. At this time, America seemed to throw itself headlong into a decade of madcap behaviour and materialism. This era, also known as ‘The Jazz Age` was improvised and wild, jazz broke the rules of music just as ‘The Jazz Age` thumbed its nose at the rules of the past. Now, the ‘American Dream` became prominent and the idea of America being a land of opportunity was challenged and people came to believe that a determined and able individual could achieve anything, regardless of their social background. This was a pursuit of wealth. G.G., unlike the other two texts is set in a time where although having just came out of war, no other country imposed on America’s freedom, which I think led to freer morals and loser behaviour among the people (for example, the widespread infidelity). Unlike G.G., C.B is set in Morocco’s real costal city of Casablanca under Vichy French rule (a puppet administration for the Germans) during the early days of WWII. At this time, people from all over the world, especially Nazi occupied Europe, came to Casablanca. Some trying to escape and others, scam artists trying to get rich. It is described as a â€Å"torturous refugee trail† to reach Casablanca where they â€Å"wait† for passport visas (letters of transit) to escape. The social setting of C.B. is presented to us as we see a globe revolving slowly at the beginning of the film. An authoritative male voice gives us the time setting for the film. The main action of the film covers three days in the life of Rick Blaine, an American who has fled from Paris as the Nazis occupied it. He has set up a cafà © in CB as he tried to forget his past and a disastrous love affair. â€Å"Rick’s Cafà © Americano† is the most popular hang out, a place where shady dealings and gambling take place. T. differs from both texts as it celebrates the day-to-day and the wit and humour the mundane. Unlike G.G. and CB, T is not remotely glamorized. However, T and CB are alike in the sense that both texts contain people who strive to gain their countries independence. The setting of the play T. is a small rural Irish speaking community in the fictional townland of Baile Beag in County Donegal. The year is 1833 and Ireland is under British Rule and part of the British Empire. It is a community of tenant farmers and fishermen where inhabitants eke out a living from the land by growing potatoes by fishing or by rearing livestock. The local people worry about the possibility of potato blight, unlike the people in CB and GG who are hungry for achieving money through business and corrupt practices. The people of Baile Beag are dependent on the land, this is poignant considering the play is set not long before the Great Famine. There are very few employment opportunities in the area and people are shabbily dressed, whereas in both alternative texts the main characters have a demure fashion sense and look to be rich. However, like CB the people are eager to flee their county in T. Emigration is among the options available to those who want to better their situation. The British army arrives in Baile Beag to conduct a survey of the area in order to make a new map and the soldiers are required to anglicise the place names as they go along. The changing of the ancient place names will have a ruinous destructive effect on the culture of the area. The new English names are both meaningless and empty. Another aspect which I feel is a central factor in all three texts is the role of both men and women and how each sex act towards each other. The three narratives reflect similar values in relation to males being the dominating sex and often in a negative context. They are commonly the bread winners and superior to women. In GG, Tom Buchannan is very negatively portrayed. He is powerful and aggressive. We see Tom’s belligerent personality when he is physically abusive to Myrtle by breaking her nose with his open hand. Myrtle and Tom are both married to other people, but have an affair together. Tom is self absorbed and selfish, he does not give his wife Daisy a second thought when being unfaithful. This theme of negatively portraying men is also prominent in CB, Rick is selfish â€Å"I don’t stick my neck out for anyone†. In CB, Rick is shown not to respect Yvonne. He sends her on her way with a bar man who works for him because he thinks she is â€Å"too drunk†, Ugarte responds to this action, â€Å"you cannot throw women around like that, some day they may be scarce†. In all three texts alike, men fight for the love of a woman, which is illustrated in a macho sense. In GG Tom and Jay fight for Daisy’s love., in CB Rick and Laslo fight for Ilsa’s love and in T George and Manus fight for Marie’s love. Aspiration and optimism i s a common factor across the three texts. Daisy aspires to make it work with Tom, Ilsa wants to work her relationship with Laslo out and Marie will rekindle her love â€Å"when George returns†. All three women live in hope for a better tomorrow. The role of women is a common feature in each the texts. In all three women have no independence; they rely on the men to provide for them. They do not work and are all seen as weak. They are all dominated by men and accept this fact. In GG, Daisy is rich and lives a luxurious lifestyle. Daisy is a lazy character, â€Å"She made an effort to rise† when Nick entered the room but was â€Å"paralysed with happiness†. Daisy states, â€Å"I’ve been lying on that sofa for as long as I can remember† and says â€Å"We ought to plan something† to Jordan. However, she is presented as being unhappy â€Å"she cried and cried†, she describes her own daughter is seen as being a â€Å"beautiful little fool†. Daisy also engages in an affair wit h Jay Gatsby, the culture causes Daisy to behave in this immoral manner. In CB, women rely on men to make a life for them and free them from the confinement of Casablanca. They are portrayed as being vulnerable. Ilsa relies on the men, Rick or Lazlo to get her the letters of transit. The women in CB conform to the traditional roles In T. again, women have no independence, they depend solely on men to work and provide for them. Sarah succeeds in overcoming speech difficulty, but is then worse at the end of the play. She is presented as being weak and shy. She has a â€Å"waif-like† appearance. In my opinion, Sarah symbolizes the suggested fragility and vulnerability of women. But, Marie on the other hand is a strong character. She is a hard worker â€Å"look at the blisters† and makes an outspoken decision not to marry Manus, solely as a means of survival. Similarly in all three texts, we capture a soft and loving side to the women; Ilsa loves both Rick and Lazlo. But these loves are very different. Daisy loves her daughter tenderly and Marie falls in love with George. Although the three texts are alike in a sense, there is a great variation in the types of women we encounter across the three texts. In GG Myrtle is a feisty character, she stands up for herself to Tom â€Å"I’ll say whatever I like† but is dominated by him, the man whom she is having an affair with. He breaks her nose and she carries on meeting with him. Myrtle’s feisty independence has only a contradiction on itself however, as she only moves from ones mans dominance to another. She is under the control of her husband who has to provide for her. Jordan also has an incurable dishonesty; I don’t think she comes across as a nice character but I do not blame the characters for engaging in such dishonesty but only the culture in which they live. Another aspect of the cultural context which I feel contributes to how and why the people in the texts behave the way the do is religion. In the world of the three texts, religion is not an integral part of everyday life. It is not significant in their lives. Interestingly, in GG a dominant symbol within this novel is the billboard eyes of Dr. T.J. Eckleburg. The eyes symbolize the loss of spiritual values in America. The billboard was erected to promote the business of an optometrist in Queensborough – the eyes symbolize the growing commercialism of America – life in America is all about making money, a lot of money as evidenced by the wealth of people like Tom Buchanan – a man’s success is measured in terms of how much money he is worth, not on what kind of person he may be morally. The billboard, like the spiritual values of America, is neglected – â€Å"But his eyes, dimmed a little by many paintless days, under sun and rain, brood on over the solemn dumping ground.† The old-fashioned values of America, which Nick Carraway returns to reconnect with in the mid-West are completely absent from the East, God seems to have abandoned America, leaving only Dr. T.J. Eckleburg behind to stare down with his empty eyes on people who have abandoned their spiritual values in the quest to achieve material wealth. In â€Å"CBâ€Å", religion is irrelevant in their lives. They have no time for religion. We see one reference to religion throughout this film which was when Ilsa said to Rick a heartfelt â€Å"Bless you†, however this still does not suggest a religion had a major role in the text. The lack of religion, I think is due to the diverse multi-cultural society. CB is a temporary destination for people fleeing. In stark contrast, in â€Å"T† we see an abundance of religious references which show us the extent of their faith. In this society, religion plays an integral part and influences their behaviour. It is a constant feature of their everyday lives and conversation – â€Å"God save us† and â€Å"The God’s truth†. All the characters have a strong, unflinching catholic faith. Religion is used as a crutch to help people get through the harsh realities of their lives. â€Å"Sweet God did the practise crop ever fail in Baile Beag†¦ Never†, this is an emphatic statement. â€Å"Never† shows their trust and faith in God it is a solace from their meagre and primitive existence. Religion fortifies them. Religion takes place in baptisms, wakes and funerals. There is a big difference in the prevalence and strength of religion in the three texts. There is another aspect which I feel impacts significantly on how and why the people in the three tex ts act the way they do, alcohol. There is a parity across all three texts. Alcohol is used for both celebration and comfort. In GG, alcohol is prohibited. Although it is illegal, it can be seen everywhere throughout the text. People who stayed sober were regarded as â€Å"deplorable and boring†. The ban of alcohol (â€Å"The Prohibition†) created a thriving underworld designed to satisfy the massive demand for bootleg liquor among rich and poor alike. Alcohol is seen as a source of comfort for Daisy on her wedding day to escape the harsh reality of not having Tom â€Å"as drunk as a monkey†. The reckless abuse of alcohol is also something that contributed to the death of Myrtle. â€Å"GG† is unlike â€Å"CB† where alcohol is seen as a way of socialising in this society. All the action throughout the film takes place in Ricks cafà © where alcohol plays a major role. Similarly to â€Å"GG†, we see alcohol being consumed for both celebration and comfort. Ricks toast to Ilsa â €Å"Here’s looking at you kid† with champagne is seen as them using alcohol to celebrate their future. Although we see Rick angry, bitter and so deeply hurt by the return of Ilsa that he drinks heavily. In Ricks time of despair he lashes out at Ilsa as a result of alcohol which is the only time we see the abuse of alcohol. However, in â€Å"T† alcohol is used as a sign of celebration whether it religious or social. When Owen returns home he promises his father â€Å"You and I are going to get footless drunk†. Hugh is seen to always of has consumed an amount of alcohol and never appears sober. I feel alcohol is a key factor that results in the people of the narratives acting the way they do. The final aspect I will explore which I think influences the varied societies to behave in certain ways is their social status, wealth and poverty. There is a stark contrast in the event of wealth in all three texts. In â€Å"GG† there is an abundance or wealth, opulence and extravagance. The majority of the characters live in an area of over indulgence. We learn that Tom gave Daisy a â€Å"string of pearls valued at $3500†. Social snobbery is prevalent for instance, servants. Jay Gatsby hosts lavish parties an there is no expense spared. His ostentatious mansion was bought to only please Daisy to try and woo her. George Wilson is an example of complete contrast to Jay, he lives in extreme poverty. The interior of his garage is described as â€Å"un-prosperous and base† In â€Å"CB† we see an obvious affluence in formal dress and gambling but not to the same extent as in â€Å"GG†. However, â€Å"CB† is similar to â€Å"GG† in the sense that wealth grants one power and freedom. Rick’s lucrative business puts him in the position of authority but in my opinion the transit papers appear to be the most valuable currency. â€Å"T† is the antithesis to the other two texts. The society is present as primitive and destitute. People are poor peasants who are dispossessed. The annual salary for a teacher is 56 pounds, thus highlights the poverty in contrast to the other two texts. I think there is a strong sense of stagnation in this text. There is a lack of finance reflects in the lack of health care and â€Å"infant mortality†. Maire knows she has to learn English to move forward economically. There are gedge schools where children are educated in comparison to the mansions in the â€Å"GG†. Malnourishment is prominent and is due to the lack of proper food. Sarah is described as â€Å"waif-like†. Through my study of the comparative texts, I have found that the cultural context of the narratives impacts on how and why the people behave the way they do. It allowed me to establish a greater understanding of the characters themselves and to appreciate the circumstances at a deeper level in the lives of the protagonists.

Global Warming Challenge Essay

One of the greatest challenges earth is facing is Global Warming. The global warming hypothesis orginated in 1896 when Svante Arrhenius, a Swedish chemist, developed the theory that carbon dioxide emissions from the burning of fossil fuels would cause global temperatures to rise by trapping excess heat in the earth’s atmosphere. The term â€Å"Global Warming† signifies the temperature of the earth’s neon- surface air. The change in climatic conditions is one of the impacts of global warming. It is directly impacting on rising sea levels and the melting of ice. It is a threat to life on earth. The effects of global warming have been increasing significantly for the past decades. Climate change, devastation of the ecosystem, water contamination, melting ice over Arctic and Antarctic regions, negative impacts in the agricultural sector are just the problems caused by global warming. The reason behind this is human activities that lead to release of greenhouse gases. The concentration of greenhouse gases has significantly increased since 20th century. Some Scientists believe that there is an increase of 0.5 Celsius in earth’s temperature since 1900 and will continue to increase. The year 1990 was said to be the hottest year in the last century. We Human Beings have created an imbalance between life and nature that has led to flood, cyclones, landslides, tsunami, drought, etc. If this imbalance continues, soon our life on earth would be difficult. The increase of Carbon-dioxide in air is one of the reasons for warming the earth’s surface. The most significant greenhouse gas is actually water vapor, not something produced directly by humankind in significant amounts. However, even slight increases in atmospheric levels of carbon dioxide (CO2) can cause a substantial increase in temperature. When the earth’s surface warms up it will eventually lead to evaporation of water. Water vapor, itself is a greenhouse gas. It is believed that the increase in CO2 in the atmosphere will continue due to ongoing burning of fossil fuels and deforestation. Not only CO2 but other gases such as methane, CFCs, nitrous oxide, tropospheric ozone are also responsible for global warming. The increase in these gases is due to industrialization, deforestation, urbanization and increasing population. Nature has given us a mechanism to decrease the content of CO2 in atmosphere but we are exploiting it. Trees are the mechanism given to mankind as a gift from nature. Trees convert CO2 gas into Oxygen. This helps to decrease the CO2 content in atmosphere which eventually helps us prevent  global warming. The question that should be put forward now is that if this mechanism only won’t exist then how will we prevent global warming? Human beings have always been exploiting nature. Trees have been cut down for the benefits of humans without realizing that it is going to affect us eventually. Deforestation is responsible for 25 per cent of all carbon emissions entering the atmosphere, by the burning and cutting of 34 million acres of trees each year. Everyday over 5500 acres of rainforest are destroyed. Increasing population is also one of the reasons for global warming. Approximately, 80 per cent of atmospheric C02 increases are due to man’s use of fossil fuels either in the form of coal, gas or oil. Vehicles with poor gas mileage contribute the most to global warming. Besides, the sulphur group gas is the most harmful for this. Its contribution is 30 per cent in global warming. This gas is also emitted from the burning of fossil fuels. One of the effects of global warming is rise in sea-level. It will lead to melting of glaciers and changes in rainfall patterns. The rate of melting glaciers have been increasing since the past decade. . The shrinking of glaciers is going to pose a major problem of drinking water. The sea levels as a result of melting of glaciers have risen from 0.35 mm to 0.4 mm. Scientists have warned in their reports that most of the glaciers will disappear within a period of 15 to 25 years. It will create problems of drinking water and food grains in most of the North American countries. India is not unaffected from it. The Himalayan glaciers have shrunk about 30 per cent after 1970. The rise in sea levels is a major cause of concern. A large number of cities located in coastal areas will submerge in the sea. Besides, many island countries will ultimately lose their existence and will be washed away from the surface of the earth. In India this effects may also threaten the Lakshadweep islands, Mu mbai and deltas of Ganges (West Bengal), Carvers (T.N), Godavari (AP) and Mahanadi, Orissa. India is also affected by global warming. As India is an agricultural country, it is largely dependent on rainfall but due to irregular rainfalls caused by global warming, the yield is decreasing every year. The rise in atmospheric temperature and fall in rain would naturally result in decline in crop production. Moreover, it would have great effect on biodiversity as well. Forestation can be of great help in this regard. Planting more trees worldwide will help restore the imbalance. Secondly, we must follow on environmental policy of ‘reduce,  reuse, recycle’, i.e. promoting the reuse of anything. Thirdly, the use of fuel-efficient vehicles should be promoted as these vehicles have lower emissions of harmful gases. Fourthly, every individual should be aware of the importance of the protecting environment. Besides, eco- friendly technologies must be promoted, and must be substituted with the technologies which cause great emission of global warming gases. Many government agencies around the world are very interested in maintaining fossil fuel use, especially coal. Furthermore, we are not going to run out of coal in the near term (oil may begin to run low sometime after 2010). Methods for reducing carbon emission levels while still burning coal are now investigation by government and industry, as we now discuss. It is too late to debate on global warming. We need to take some measures to decrease global warming. Forestation can be of great help in this regard. Planting more trees worldwide will help restore the imbalance. Secondly, we must follow on environmental policy of ‘reduce, reuse, recycle’, i.e. promoting the reuse of anything. Thirdly, the use of fuel-efficient vehicles should be promoted as these vehicles have lower emissions of harmful gases. Fourthly, every individual should be aware of the importance of the protecting environment. Besides, eco- friendly technologies must be promoted, and must be substituted with the technologies which cause great emission of global warming gases. We should control the growth of population by decreasing birth rate. This can be done by proper family planning. We should reduce the use of chlorofloro carbons. More use of non-conventional source of energy like wind power and solar energy. It is said that â€Å"There is no place like home† and earth is our home so we need to protect it. Policies are made every day but do we follow it? The answer is â€Å"No†. We all are aware of global warming so we need to change the way we think that we can’t do anything and only the rich who are seated in the seats of government can save us. Who you are, whatever you are you can do something for your planet when you think global warming is a problem.

The Decisions for Miller Lite Brand Essay Example | Topics and Well Written Essays - 750 words - 20

The Decisions for Miller Lite Brand - Essay Example It is observed that with the return of Miller Lite’s original white can design, the sales in the American market immediately increased. That compelled the MillerCoors to make the white cans permanent. The second reason behind the change to the original package is that MillersCoor’s share of the North American beer market has been declining. For instance, in 2005 it reduced from 7.9 percent to 6.2 percent (Wong, 2014). Third, the blue can design makes people think or feel that they are not buying the same old Miller Lite. For instance, it is depicted that diverse people insinuate that the beer tastes better because of the white can. A significant challenge is that light beers are often blue such as Bud Light, which is America’s best-selling beer. Therefore, it would portray wrong publicity that it does not have hence it was proper for the MillerCoor’s marketers to return to the original white can to set a distinction. The decision to back the white can design is justified. It is an economically wise decision to return the Miller’s original packaging. The main reason is to market the product. It is evident that the change of the beer cans from blue to white promoted the sales in America, as there were no more beers remaining on the shelves. The decision to change the packaging has enormously boosted the brand positively. The brand has gained momentum in the market as consumers now view it as taking quality and original beer. The white packaging makes it unique from other drinks hence making the brand to be popular. Besides, the brand has gained recognition and improved sales. In addition, the change of packaging to white design cans has made the brand marketable in tests with a panel of men of ages between 21 and 29. The decision to change the packaging was actually expected as a measure to boost the sales. It is evident that Miller Lite’s blue can design has been in the beer aisles from 2001 with low sales. Therefore, there was a need for a solution to boost the market hence the decision to change the packaging was expected.

Final Exam Essay Example | Topics and Well Written Essays - 500 words - 8

Final Exam - Essay Example The Point of Sales as suggested by Salgado due to the reasons given by him. One, that they are overtaken by technological advancement since they still run on DOS which is not supported by Microsoft currently. In case the company will need to advance to other markets as a strategy, it would be hard since technological connections would be impossible. The operational section for Zara is already effective and as much customers are able to make orders. Fulfilling such customer needs since they are many is a challenge hence the company should apply an IT system which will improve such an efficiency (MCAFEE, VINCENT and ANDERS). This will ensure they run their own activities to satisfy customer orders and save on costs as well. Due to heightened competition, Zara should use technology to produce the new designs of production from three weeks to a lesser period to aid increase of their supply. In this way they will be able to respond to customer preferences in time. The company should also establish stable IT departments which will handle technological matters in time ensuring their operations abroad are never affected due to technological failure. Organizational efficiency is all about constantly improving the functional performance of Zara and hence the leadership and control of the manager will be in handy (MCAFEE, VINCENT and ANDERS). Organizational and cultural challenges facing Harley in deploying IT to manage business are several. Lack of diversification made the company be in the position of not being able to establish firms on the foreign countries, this reduced the need to apply IT solutions in running the firm due to central management. Secondly, we witness financial mismanagement which makes the company be bankrupt. Bankruptcy is an issue since it affect the financial decisions of the company and those decisions other than investment decisions will always be given preference when a company is bankrupt. The company culture of quality manufacturing

Proceses in Organinzations (Project Managers) Essay

Proceses in Organinzations (Project Managers) - Essay Example Planning, organizing, and controlling are the three main responsibilities of any project manager. A project manager needs many skills to execute these responsibilities. Project planning involves the task of defining the project objective and developing a plan to accomplish the objective. The project manager works with the project sponsor to define the specific objective of the project. The project manager must also develop a plan to accomplish the objective. He involves the project team members in this phase. Past experience and sound judgment is the basis for the planning process. Project organizing involves identifying and procuring the necessary resources for the project, determining the tasks that must be completed, assigning the tasks, delegating authority, and motivating the team members to work together on the project. Resources include personnel, capital, and material. Project controlling involves the task of tracking project progress and comparing it with the planned progress. Progress reports are used to measure the performance and to identify the areas for improvement. The project manager must be capable of solving the problems and getting the project back on track. The project manager must observe how the project is progressing from a higher perspective. He should know when to take action. The project manager must be equally adept at handling a team conflict, steering committee meeting, and coaching session with an end-user. Effective listening is a large part of successful communication. Interpersonal - To develop a relationship with every team member and to motivate them. Patience and commitment to the team are important factors to gain the team's trust. The project manager must exhibit integrity. Problem-Solving - To anticipate problems, identify them when they occur, and solve them quickly. Time Management - To prioritize, delegate, and manage time effectively. Project managers must adapt to ever-changing project conditions and manage the team's actions. Human resources - To interview and select team members with the proper skills and knowledge. Project managers must also have the ability to give feedback and help the team members learn, as it boosts their value. Conclusion The project manager has the primary responsibilities of planning, organizing, and controlling a project. An effective project manager must also possess a specific set of skills in order to manage projects successfully. The project manager must possess skills in business literacy, technical competency, and organizational awareness to make technical, business and appropriate information system decisions. Project managers must have the ability to understand complex systems including organizational, social, and technological systems. Technology is always changing and at a fast pace. Project managers must be ready to develop differing skill sets to keep up with this change. Most importantly, the

Professional Portfolio Essay Example | Topics and Well Written Essays - 500 words - 1

Professional Portfolio - Essay Example Learning is an active process, which requires patience, dedication and confidence. Teaching nursing student involves evaluation, which can serve a number of services such as providing relevant data for decision making, diagnosing problems and improving the learning outcomes. Ambitious students enter into a learning process with the willingness of being evaluated so as to give them a guarantee of how they are fairing in their career. In the same way, good teachers should be capable of putting forward the methods, which they intend to use throughout the evaluation process. I am an evaluator; I take this as one of the many methods of scrutinizing learners in this practice. Essentially, I give a learning setting of a classroom with a topic of administering oral medication to patients. Its main purpose is to encourage critical thinking and excellent communication between learners and the patients. This also ensures that learners develop cordial relationship with patients’ staff and instructors. Moreover, I evaluate the learners through oral presentation. Oral presentation entails learners being able to communicate to patients properly at all times. This contributes in building confidence and demonstrating their oral communication skills. In fact, every learner is expected to give a presentation on how to administer to patients and monitor the changes that are present in patients pertaining to their diseases. Further, the learners should be in a position to give explanation of what should be done in case patients do not respond positively to the prior medical dosage. I am a dedicated nursing educator. I am aware that nursing is a sturdy job. This means that I must portray an infinite dedication that should be imitated by the learners. I demonstrate this by evaluating the ability of the learners while he/she is recommending proper oral dosages that are forwarded to me in writing. In the writings, learners are expected to describe the procedures that

Improvements of the marketing planning process in the pharmaceutical Essay

Improvements of the marketing planning process in the pharmaceutical company - Essay Example Product group should be appealing to the contemporary market. Assuming social responsibility, and employing competent and trained labour forces are also important. Production should be doen in compliance with the EU directives.More aggresive acquisition, promotion and advertising should be undertaken. Company Introduction ACTAVIS AD (formerly known as BALKANPHARMA) a generic pharmaceutical company was founded in 1999 due to privatizations of its three manufacturing sites at Dupnitza, Troyan and Razgrad, with a manufacturing tradition of half a century. It the Bulgarian branch of the MNC generic pharmaceutical group ACTAVIS HF (earlier PHARMACO). The group head quartered in Iceland has its operations in more then 25 countries. Actavis AD is the leading generic pharmaceutical company in Bulgaria enjoying substantial market share both in terms of value and volume. Currently operation and production have been segregated from marketing and sales and Actavis represents the marketing and sales aspect. The ratio of domestic sales and export sales is also significant (51%/49%). It continues to enjoy the traditional favored position both in the domestic market as well as in USSR. The entire capital and is owned by the mother concern and Actavis is the biggest tax payer in Bulgaria. It is the driving force in th e Bulgarian domestic pharmaceutical market. Several restructuring has taken place to divert it focus from the safe and closed market to the more competitive open market. Ongoing efforts to incorporate the Good Manufacturing Practices into its manufacturing facilities are on. To counter foreign and domestic competition various aspects are being developed. ACTAVIS AD in 2002 became the only European pharmaceutical company with a... An analysis of   the market status of Actavis AD   within the Bulgarian pharmaceutical industry, along the significant economic   determinants operating in all markets, namely, supply and demand, barriers to entry and the pricing of goods, production cost and profit, aids in understanding the company’s market status and in devising future strategies.Within the Bulgarian pharmaceutical sector the demand is mostly created by the public funds, namely National Health Reimbursement Fund; hospitals and Ministry of Health centralized tenders. The demand market is differentiated along three parameters, namely those goods which are reimbursed and those which are free sales ones; those which are for sale in hospitals and those which are sold at pharmacies; those which are patented and those which are generic. There is a possibility to enhance the demand in the pharmaceutical market. The supply market can best be represented by the volume in the pharmaceutical market. The market su pply volumes merely indicate the part of the demands which has been satisfied, the actual sales. Actavis Ad enjoys significant market volume (35% in terms of market volume share and 18% in terms of market value share). It emerges as the clear leader outrunning its major business rival Sopharma by 8% in terms of market value share. Despite the small size of the Bulgarian pharmaceutical market(Polish market being ten times bigger) Actavis has recorded a significantly high growth rate attributed to it’s ever expanding portfolio in generic products, commitment.

Healthcare Reforms Essay Example | Topics and Well Written Essays - 1000 words

Healthcare Reforms - Essay Example e services available to customers; and to cut the healthcare costs (Kronenfeld & Kronenfeld, 2004). The Obama administration has introduced a range of far-reaching reforms of the healthcare system, the most comprehensive since the adoption of the Medicare act in 1965 (Parks, 2011). This paper will review these health care reforms since health care reforms would be beneficial by reducing the overall price per family requirement and medical treatment delivered. Having these basic necessities available would make living in this country easier on the mind as well as the wallet. Having the ability to use the hospital’s resources in a time of need is a common resource not readily available to all Americans.The combined public-private healthcare scheme that was in existent before the healthcare reforms of 2010 was one of the costliest systems globally, with the costs of health care being the highest per individual as compared to any other country (Parks, 2011). Besides, United States comes second, after East Timor, in terms of the percentage of gross domestic product (GDP) that is used on healthcare among the member countries of the United Nations (Parks, 2011). An independent research on global patterns of spending on health care indicates that United States uses more than any other member state in the Organization for Economic Co-operation and Development (OECD) (Williams, 2011). Regardless of the massive spending, the research indicates that usage of health care servicesis lower thanthe OECD standards by most indicators. In addition, the findings show that costs incurred by individuals for various health care services are appreciably greater in the US (Williams, 2011). Therefore, these healthcare reforms are a relief to most American families as they will have access to more affordable health care resources and services whenever they need them. For instance, they introducecost-free preventative services, prohibition of insurance companies from barring person s with pre-existing conditions from getting their policies among many other comprehensive benefits to citizens (Williams, 2011). Opponents of these reforms argue thatincreasing the hospital’s resources to the general public at a no-cost rate would spark greed. They suggest that these patients and hospitals alike would disregard the cost and expect the government to front the bill. However, this is not true; the fact is these reforms do not make the system a single-payer scheme in which the state has total control over the health care. The changes would still retain the private insurance system (Parks, 2011). The reforms are only intensifying government’s regulation over health care insurance providers. Besides, an alternative for a public insurance scheme, administered in a similar manner to Medicare, brings in additionalstatefinancing into health care and willchange the market whilstchallengingthe private insurers in an exchange (Parks, 2011). The fact is that a publi c schemeincreases the government’s regulation but it is not a takeover of system. Health care reform

Explain the most important concepts in the business-supply chain Assignment

Explain the most important concepts in the business-supply chain relationship - Assignment Example This will entail finding these suppliers closer to the supply points and ensuring a commitment to long term cooperation. Additionally, this concept should be focused on buying production capacity and not just product quantity. Proper distribution structures is the other concept that serves to put the company close to the suppliers at all times. Through this concept companies can create good business relations with the companies involved thus monitoring their product while at the same time gain new ideas. Still under distribution, companies can seek for ways to lower the costing of its products. Here, the company tries to shorten the route from the manufacturer to the customer. Another way to make better the distribution is by proper packaging to increase efficiency in transportation. For instance by selling products that are packed flat, a company can increase â€Å"the filling rate† in containers etc (or simply reduce the amount of wasted space), thus reducing cost of transporting each item. The third principle is contracting, which seeks to develop long-term agreements with suppliers thus giving lower product prices. Here, bigger volumes are translated into lower prices of goods. By entering into long term contracts with suppliers companies are able to ensure uninterrupted supply of goods and raw materials to distance places. Sustainability is the last concept identified in this work with regard to business-supply chain relationship. Here, the product life cycle is made to reflect the required quality, safety and environmental aspects. Products are made to comprise a higher percentage of renewable or recyclable

To what extent was the First World War a catalyst for change in the Essay

To what extent was the First World War a catalyst for change in the Middle East - Essay Example Political The First World War shaped the Middle East by having its unity disbanded in a brutal manner that paved the way for the modern Middle East known to man in the present day. As such, the First World War set the stage for a series of never before witnessed events that have been in play to the current times in that there have been revolutions and reforms that have seen the Middle East become a widely divided location especially in terms of modernity and development (Iran Review 2012). Traditionally and conventionally, the borders of the Middle East were not clearly defined and two parties, mainly the chieftains, controlled them and the British coupled with the French. This was prior to the First World War, in which case the nation was largely united under a common religion and a form of belief in a single ethnicity. This was in spite of the presence of factions that were divided on religious and ethnic grounds because of the death of the Islamic prophet. In this case, there were significant revolutions in Iran and neighbouring lands of modern times where there were riots against the Iranian monarchy led by merchants in an attempt to cut back on the powers of the absolute monarchy that arbitrarily shifted its powers back and forth over the people. Prior to the First World War, the leaders who served administrative duties ceased to function due to lack of political support by the people. It was after the First World War that the monarchy received a substantial blow, which saw the monarchy weaken to the extent of having a mark on Iranian history. The culminations of the First World War set the stage for future confrontations against the governments of the time by causing massive disunity between the monarchy and the people to the extent that after the constitutional revolution, the Islamic revolution took place. Without the presence of the First World War and significant weakening of the monarchy, the Islamic revolution of 1978-1979 would not have taken place and the urban middle would not have participated to bring about change. In addition, the First World War saw the Middle East thrown into a state of turmoil or chaos following the constitutional revolution. This allowed the people to have greater control over the happenings in Iran, which was significant for the overthrowing of the then government. This was done in the early years that followed the world war through a military coup that saw Zia thrown out of power in 1923 and saw the establishment of new government after deposing the then monarchy. This set the stage for modern day Middle East, as we know it due to the rapid shift in power and the impact that other coups occurring in Europe had. This also had plenty to do with the crowning of Qajar Shah in 1921 and invasion by the Ottoman Empire, British and Russians. It is these events, of the first war, that also saw significant disunity in Iran and the open view that the government had no power whatsoever. As a result, of the Fir st World War, the stage was set for drastic change that lasts to date in that there have been significant uprisings against governments in an attempt to get improved governance and proper leadership, as well as reforms. Moreover, the First World War saw the development of numerous changes in modern times as seen in the case of the Hussein-McMahon correspondence that shows the great influence the First World War had in the Middle East. The above-mentioned correspondence saw Hussein seek

Flowers, herbs and willows Essay Example for Free

Flowers, herbs and willows Essay Also, the fact that Shakespeare did not add any stage directions to the play helps the director portray the protagonists in the light they see fit. This has granted directors the licence to portray Ophelia as either virginal or sexually knowledgeable. Brannagh uses the device of flashbacks to perfectly show his audience that he sees Ophelia as being less than innocent and that she and Hamlet have previously been sexually active. He does this without taking anything away from the script and gets his point across using a dialogue-less scene. However in the most recent silver screen version of Hamlet directed by Michael Almereyda, Ophelia is portrayed as being virginal and innocent as no sexual references appear during the film. This shows how different the character of Ophelia can b portrayed, almost as they were two separate individuals. The lack of stage directions not only makes it simpler for directors to portray her the way they want, but also for the audience, as they dont have to decide whether she was innocent or not for themselves, but have it done for them. The third interpretation of Ophelia is that if her being sexually active. The scenes in which she goes mad strongly suggest her sexual knowledge comes from her own experiences with Hamlet, as she acts in a sexual manner. The songs she sings during her madness are also of a sexual nature, which further points to her being sexually active. There is evidence of sexual activity in Branaghs production, during the previously mentioned flashback scenes. Richard Corum also supports the view that she was sexually active, however Shakespeare never states whether she was a virgin or not Her conversation with Hamlet in act3 scene2 strongly suggest that she and hamlet have had sexual relations, you are keen, my lord, you are keen. The keenness may be that of his sexual lust and she teases him by pointing it out. However much this may point towards the idea that they both have had sexual relations, Shakespeare still never specifically says whether she is a virgin or not. Richard Corum investigates the symbolism and significance of the flowers, herbs and willows, that Ophelia talks off in chapter nine. Corum implies that through the flower imagery that Ophelia uses, it is undoubtedly obvious that she is not innocent. The flowers symbolize Ophelias wishes to regain her lost purity and to once again become an innocent flower. The fennel that is mentioned represents the fickleness of love. Folklore of the time also suggests that fennel and rue were abortion-inducing agents. The willow which Ophelia was holding when she was found dead, was also thought to hold the same properties, which means that Ophelia attempted to abort a pregnancy before the died. Furthermore, the term flowers was used at the time as a term for menstruation, which suggests that Ophelias interest in rosemary was a way of her trying to tell herself that her menstruation cycle continued as is normal, meaning she was trying to convincer herself that she was not pregnant. Corum also states that rue supposedly made men impotent and that in handing it to Hamlet, Ophelia was trying to prevent a situation that is now perhaps unpreventable Corums examination of the flowers in Act 4, Scene 5, seems to be viable. This is mainly due to his study being based on folklore that existed in Shakespearean times. The ideas themselves are plausible as they clearly fit into the character of Ophelia and can be related credibly to her apparent affair with Hamlet. Instead of outright stating Ophelias sexual knowledge Shakespeare uses this symbolism and imagery as subtle undertones to incorporate the idea of her sexual exploits. Shakespeare has always had strong-minded female protagonists in his plays, which means that the assertion that Ophelia is a character of considerable aptitude is not a new phenomenon. Lady Macbeth for example is the driving force behind her husbands ambition and influenced him to kill the king. Juliet is another astute and determined character despite her young age, her character proves that women can challenge the authority of the men, as she does with her father by marrying Romeo. Taking the conception of Ophelia being a strong minded and autonomous character would by no means be extreme, as the examples I have given surely provide enough evidence that Shakespeare has presented female characters as being of a significant standing.

Media Technologies And Journalism Media Essay

Media Technologies And Journalism Media Essay In the second half of the twentieth century and early of the twenty-first, along with the advancement of new media technology, we have witnessed the dramatic transformation of journalism. There can be no denying that the technological revolution has exerted far reaching influences on news journalism and its production. In 2000, Pavlik (p.229) has asserted: â€Å" Journalism has always been shaped by technology†. Pavlik as well as many academics in the field of mass communication believe that the profound changing of journalism are technologically determined. However, there are some researchers who criticise the idea of technological determinism. They argue that technologies not only transformed journalism but also were shaped and operated in the news production process. As Cottle (1999,p.22) has stated: â€Å"news technologies of news production are in fact socially and culturally shaped and embedded within corporate and professional contexts and practices†. It could be argued that the relationship between technology and journalism is not simply a cause and effect relationship, in fact, they changed and determined each other. The aim of this essay is to examine the interaction relationship between technology and journalism, with a particular focus on how new media technologies transformed news journalism. This research paper will begin by consider the impact of technology on journalism, and then account for the way that technologies are operated and integrated in the news production process. In the second section, the proliferation of the internet and blogs will be taken as prime examples of technological advancement which has offered opportunities as well as challenges to journalists and news organisations. Finally, the assignment will discuss whether technological changes and the adoption of new technology have led to the improvement or deterioration of journalisms quality. 1. The interaction relationship between news media technologies and journalism For the purpose of this assignment, this section will briefly introduce the theory of technology determinism as well as critical arguments of modern social scientists. The impact of new media technologies on news journalism will be examined and references are made to the work of academic in this field. Furthermore, evidence is provided in order to account for the way technologies are shaped and integrated in news production process. 1.1. The impact of new media technologies on news journalism According to Pavlik (2000,p.229), journalism are transformed by technology in four broad areas: practices of journalists, news content, the organization of the newsroom, and the relationship between and among news organisations, journalists and their many publics. â€Å" Technological changes have had an impact above all on the immediacy and availability of journalism as it has proliferated as a mode of communication† (Conboy,2004,p.205). 1.2. Technologies are shaped and integrated on news production process With a critical argument, Cottle (1999) views technology as a â€Å"creature of our own making â€Å", in his words, â€Å"which inhabits, was born out of, remains dependent on, and is socialised and put to work within determinant social environment† (p.23). In his study of â€Å" A combination of political regulatory change and the arrival of the new media organizations and products has introduced considerable competition into the broadcast environment..this competition appears to be the immediate cause of organisational and technological change† (Ursell, 2001,p.194). New operations have adopted new technologies with different degrees of extent and intensity (Ursell). Consequences for journalist: demand for and pressure on journalistic staff have increased. 2. Technological changes and the quality of journalism 2.1. The internet and blogs: a nascent phenomenon Internet: how it changes the newswork -> journalist practice(Pavlik), mot-used new resources for finding imformation(Garrison), journalist easily interact with audiences Define blog Bloggers 2.2. Quality of journalism in era of new media technologies: deterioration or improvement Though there can be no denying that the appearance of the internet and blogs has changed news journalism in many ways, it is now essential to consider whether it is better or worse journalism. Thus, this question has been the subject of a great deal of research. Ursell (2001) in his study of Convergence: â€Å" I assert that convergence merely holds the promise of a better, more efficient, more democratic medium for journalism and the public in the twenty-first century† (Pavlik,2001,p.xiii) Multi-skilling: High-Speed: â€Å"Speed is in danger of becoming the ultimate aim of journalism. The post-telegraph compulsion to beat competitors to a story, accelerate by new technologies, can mean it becomes more important to be first than to provide an adequate assessment of context† (Conboy,2004,p.207) â€Å" The pace of breaking news drives the possibility of in-depth analysis further down the line† (Conboy, 2004,p.207) â€Å"All of this compromises the incredible speed and technological sophistication of the journalism produced as it is often lacking in analytical depth or political variety† (Conboy,2004,p.207) Journalists who are under the pressure of becoming multi-skilled and technically competent to produce multiple media production do not have much â€Å"opportunities for creative reflection or innovation†(Cottle,1999). To illustrate this point, Cottle(1999,p.41) has quoted a statement of one broadcast journalist: â€Å"We dont have time to be creative. Its not that the equipment will not let us be more creative as we used to be†. Pavlik (2001) states that, on the plus side, new media technologies has offered potential for improving quality of journalism as well as helped journalist do their jobs more effectively. In other words, journalists can use new technologies to create much more â€Å"engaging, navigable, contextualized† news productions which reflect everyday life more â€Å"accurately, fully, and dynamically†(Pavlik,2001,p.xvi). However, on the negative side, â€Å"We journalists are no longer the gate keepers in the market place of ideas. The doors have been flung wide open by the egalitarian nature of the Internet and when you look at the big picture you see chaos. You see a medium in its infancy, howling and kicking against the limitations of the world into which it was born. Conclusion To bring this paper to a close, I summarise the main points here: new media technologies have transformed news journalism and its production, at the same time are shaped and operated in news production process. This essay set out to examine the intertwining relationship between technology and journalism, consider it in both positive and negative side. In the first section, it produced some insights into how journalism is influenced by technology and answered the question of how technology are shaped and integrated in news production process. In an attempt to demonstrate this point, evidence was presented relating to the change in news-making activities of journalist in the era of the internet and blogs. Finally, the evidence presented in this paper suggested that technological changes have had diverse impact on the quality of journalism. In other words, technological innovations lead to improvement as well as deterioration of journalism performance and output.

How Does Technological Advancement Eliminate Genetic Disease

How Does Technological Advancement Eliminate Genetic Disease Amy Chong How Do Technological Advancement, Combined With Our Extensive Knowledge From The Human Genome Project, Help Us To Eliminate Genetic Diseases? Abstract The aim of this project is to answer the question how do technological advancements, combined with our extensive knowledge from the Human Genome Project, help us to eliminate genetic diseases? I want to find out more about genetic diseases, such as Myotonic Dystrophy and Cystic Fibrosis, and the stage that scientists are at in curing patients. Ill explore the ethical issues of possible gene editing in the future. Ive carried out a lot of research on the background of genetic diseases and one could speculate that gene editing could eliminate diseases within the next decade or two, if technologies continue to expand at the current rate. This report has enabled me to recognise the work of scientists and furthermore, encouraged me to pursue a career in STEM[DS1]. Introduction History of the Human Genome Project The Human Genome Project was a ground breaking discovery in the understanding of how we evolved as human beings (Carey, 2015). Their aim was to map and understand all the genes for building human beings by going through 3.2 billion bases. A genome can be defined as an organisms complete set of DNA, including all of its genes (Genetics Home Reference, 2016). This research has clearly revolutionised genetics as the cost of gene editing and testing has decreased by 99 percent (Kurzgesagt, 2015[DS2]). Methodology My research is based on secondary qualitative research from published journals, scientific reports and books. It didnt cost any money to conduct. Ive approached my question through Jennifer Doudnas lens on future technology such as CRISPR to eliminate disease. Theyre all diseases that have known genetic causes, and we now have the technology that can repair those mutations. (Jennifer Doudna, 2016). Ill apply CRISPR in contrast to current technologies used. DNA Coding What is the genetic code? DNA is made up of many nucleotides containing three molecules: a deoxyribose pentose sugar, a phosphate group and a nitrogenous organic base. These bases are Cytosine (C), Adenine (A), Thymine (T) and Guanine (G) (Toole, 2015). How does genetic codes link to genetic diseases? Three bases code for an amino acid. The code is non-overlapping which reveals theres only twenty different amino acids present in proteins. Changes to the base sequence or quantity results in a mutation. There are four types of mutations that can occur during DNA semi-conservative replication: nonsense, missense, silent and frame shift. Any of these changes to the DNA sequence leads to gene mutation'(Toole, 2015). This is shown in figure one. Figure one Effects of single base mutation In DNA Code[DS3]. Myotonic Dystrophy From the Genome Project, its evident that the isolation of a number of genes is associated with Myotonic Dystrophy. Myotonic Dystrophy is a dominant disorder. Patients suffer from prolonged contractions, therefore are unable to relax their muscles (Genetics Home Reference,2016). The symptoms start to appear during adulthood. According to the Congenital Myotonic Dystrophy in Britain research, (1975) there are two types of Myotonic Dystrophy. Type one involves weak muscles affecting the lower legs, hands, neck, and face. Whereas type two is associated with the muscles of the neck, shoulders, elbows, and hips. The two differ due to mutations in different genes (Harper, 1975). Figure two (in appendices) reveals the muscle strength of those who suffer from this disease in contrast to a person, with average height and build, with the muscle strength of 38kg (Grassino etal.,1997:135). How does Myotonic Dystrophy differ from other genetic diseases? This genetic disease has different characteristics to a typical dominant disorder. Normally, the symptoms of genetic diseases dont get worse when they are passed on from parent to child. This is the case with Myotonic Dystrophy. The disease is unique due to the gene containing small sequences of DNA thats repeated multiple of times. Type 1 is caused by a mutation in the DMPK gene, which appears to regulate the production and function of structures inside muscle cells. The mutated DMPK gene contains three DNA nucleotides CTG repeated in the ranges from 5 to 34. On the other hand, type two is caused by CNBP gene. This consist of four DNA nucleotides CCTG repeated fewer than 26 times (Carey, 2015). What technologies have been made to eliminate Myotonic Dystrophy? Currently, theres no cure or specific treatment for Myotonic Dystrophy but there is a promising step forward toward muscular Dystrophy treatment (the University of Rochester Medical Centre, 2012). Their research involves reversing the symptoms by creating synthetic compounds that will eliminate a buildup of toxic RNA in muscle cells. This was tested on mice and results showed that symptoms were reduced for up to one year. According to Charles Thorntom (2012), these results give us strong encouragement about the possibility of developing a treatment. Is testing mice the best research method? How will we know if the research would eliminate the genetic disease in humans[DS4]? What are the implications of the research? As the cure is still to be found, it is not possible to test on humans due to limitless RNA targets involved in disease; the question is how to find small molecules that bind to them, (Disney,2012). Because of limitless RNA targets, it complicates the target amplification system. This is an enzyme-medicated process, therefore, millions of targeted enzymes are copied within several hours; the copies made would be used for research. As a result, the techniques are sensitive to contamination. This could lead to false-positive reactions which cause implications for future research (McClatchey, 2002). What has been done to prevent false-positive reactions? Perhaps the University of Rochester Medical Center should consider using Kaspersky Lab technology to test for false-positive reactions. The machine can automatically create files for results that are common or not. Results that are not common are ignored and wont affect research. This upgrade in technology would make their results more clear (Kaspersky Lab, 2015). But should they accept the false positive results as side effects of their research? Could these false positive results be significant in their research? Cystic Fibrosis   Ã‚   Cystic fibrosis is an inherited disease causing a build up of mucus to damage the bodys organs. Mucus is a lubricant that protects the linings of the airways and digestive system. People with cystic fibrosis, produces thick mucus that clogs the airways causing problems with breathing. Over time, it can permanently damage the lungs by producing scar tissues. Scar tissues are thicker and less elastic than normal tissues so the tidal volume is reduced (Genetics Home Reference, 2016). Which codes causes Cystic Fibrosis? If youre missing two letters out of 3.2 billion of the sequence, ATT CTT GATT, you have cystic fibrosis (Sabatini,2016). Mutation in the CFTR gene disrupts the flow of chloride ions across cell membrane, which is necessary to produce freely flowing mucus (Genetics Home Reference, 2016). What technologies have been made to eliminate Cystic Fibrosis? From the Human Genome Project, we know which genome codes for lungs, and with the help of stem cells and tissue engineering, scientist believe it is possible for human lungs to be successfully grown in a lab for the first time, (Medical News Today, 2014). Due to shortage of donor organs, using stem cells (which are able to differentiate in to other cells) is a desirable approach for organ replacement. Whilst the field of tissue engineering has successfully reconstructed cartilage frameworks for ears and bones in the skull and face; they struggle to use stem cells to grow lungs thatll survive and function properly (Lui etal.,2013). This means maintaining blood and oxygen supply inside the body without clotting (The Guardian, 2015). Will growing organs give a better quality of life to those who suffer from Cystic Fribrosis? Would this be as effective as gene editing technology? Gene Editing Technology CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) CRISPR-Cas9 is a technology, using bacteria, that enables parts of the genome to be cut out and replaced, or to add parts of DNA sequence.The CRISPR-Cas9 system consists of two key molecules: enzyme Cas9 (a molecular scissors that cuts a specific location of DNA) and RNA (The New York Times, 2015). Figure three (in appendices) will show the steps of gene editing. Once the DNA is edited, the mutation causing the genetic disease would be eliminated (Your Genome, 2016). Technology success Layla recovered from leukaemia thanks to gene-editing technology. For children as young as Layla, the cure rates are only 25 per cent (Sujith Samarasinghe, 2015). As a result, her doctors proceed to gene therapy to removing immune cells from her body and genetically engineer them to attack cancerous cells (Nature, 2015). She received T-cells (exposed to a DNA-cutting enzyme called a TALEN) from a healthy donor. The process was done so that the modified T-cells injected were not recognised as foreign. T-cells are significant because receptor CAR19 helps programs the T-cells to kill any cells with protein CD19 found on cancer cells. Is the process this simple? Theres a risk of the enzyme being cut the wrong place resulting cells turning cancerous (New Scientist, 2015). Research on gene editing is now expanding to minimise this risk. Soon there are a whole bunch of other disorders we cure (Qasim, 2015). Since she is the first person to be cured using gene editing does this mean its safe to proceed this process on other diseases? Ethical Issues Objective of Gene Editing As the technology is at its early stages, scientist are creating a modified version of Cas9 thatll change specific letters to remove the mutation that caused genetic disease. In most eyes, gene editing is unjust since the technology is limited to individuals. Researchers are mainly testing on reproductive cells to prevent children from having the condition. Theyre plan to carry human trial by the end of 2016. Do we know enough information for humans to participate as the effects are unpredictable? (Your Genome, 2015). Future Generations According to David Baltimore (2015) we sense that we are close to being able to alter human heredity. CRISPR is opposed by a lot of people as they want new laws and regulations to protect the human gene pool of our entire species. The process is irreversible. If technology advancement and researchers have enough information to create modified humans, we have to consider the cost. This is a valid point as wealthy parent maybe tempted to treat unwanted characteristics that are not actually diseases. Do we want stronger, smarter, taller children with specific colour eyes? Could designer babies be the answer to eliminate genetic diseases? These are the questions that pose potential flaws is the advancement of technology[DS5]. Conclusion Gene editing research and technology advancement is the step forward in eliminating genetic diseases. From my selective mention of genetic diseases such as Myotonic Dystrophy and Cystic Fibrosis, we can see technologies such as growing organs using stem cells and synthesis of compounds to cure disease are making progress. The focus of gene editing will an effective treatment if the trials are successful. This is the beginning of revolutionising human genome and eliminating genetic disease as a whole. References Carey.N, (2015). Junk DNA. London: Icon Books Ltd. Pages 7-11. CNBC, (2016). Editing our genes to cure not just treat disease. [Online] Available at: http://www.cnbc.com/2016/05/26/editing-our-genes-to-curenot-just-treatdisease.html [Accessed 31 Aug. 2016]. Genetic Home Reference, (2016). Myotonic Dystrophy. [Online] Available at: https://ghr.nlm.nih.gov/condition/myotonic-dystrophy [Accessed 29 Aug. 2016]. Genetic Home Reference, (2016). What is a genome? [Online] Available at: https://ghr.nlm.nih.gov/primer/hgp/genome [Accessed 20 Aug. 2016]. Grassino etal. (1997). Relationship Between Chronic Hypercapnia and Inspiratory-Muscle Weakness in Myotonic Dystrophy. Am J Respir Crit Care Med, [Online] Volume(158), pages 133-137. Available at: http://www.atsjournals.org/doi/full/10.1164/ajrccm.156.1.9509041#readcube-epdf [Accessed 31 Aug. 2016]. Harper,P. (1975). Congenital myotonic dystrophy in Britain. Archives of Disease in Childhood, [Online] Volume(50), pages 505-513. Available at: http://adc.bmj.com/content/50/7/505.full.pdf [Accessed 29 Aug. 2016]. Kaspersky, (2015). Kaspersky Lab Patents Automated False-Positive Testing Technology Based on Machine Learning Algorithms. [Online] Available at: http://www.kaspersky.com/about/news/product/2015/Kaspersky-Lab-Patents-Automated-False-Positive-Testing-Technology-Based-on-Machine-Learning-Algorithms [Accessed 29 Aug. 2016]. Kurzgesagt In a Nutshell, (2016). Genetic Engineering Will Change Everything Forever CRISPR. [Online] Available at: https://www.youtube.com/watch?v=jAhjPd4uNFY [Accessed 11 Aug. 2016]. Live Science, (2013). DNA: Definition, Structure Discovery. [Online] Available at: http://www.livescience.com/37247-dna.html [Accessed 20 Aug. 2016]. Lui, Yunying etal.(2013) Generation of functional organs from stem cells. BioMed Central, Page 1. McClatchey,K. (2002). Clinical Laboratory Medicine. 2nd Edition. Philadelphia: Lippincott Williams Wilkins, Page 1237. Medical News Today, (2014). Human lungs successfully grown in a lab for the first time. [Online] Available at: http://www.medicalnewstoday.com/articles/272763.php [Accessed 29 Aug. 2016]. Myotonic Dystrophy Foundation, (2012).SCIENTISTS CREATE POTENT MOLECULES AIMED AT TREATING MYOTONIC DYSTROPHY. [Online] Available at: http://www.myotonic.org/scientists-create-potent-molecules-aimed-treating-myotonic-dystrophy [Accessed 29 Aug. 2016]. National Human Genome Research Institute, (2012). A New Five-Year Plan for the United States: Human Genome Program. [Online] Available at: https://www.genome.gov/10001476/human-genome-projects-fiveyear-plan-19931998/ [Accessed 29. Aug. 2016]. Nature, (2015). Leukaemia success heralds wave of gene-editing therapies. [Online] Available at: http://www.nature.com/news/leukaemia-success-heralds-wave-of-gene-editing-therapies-1.18737 [Accessed 31 Aug. 2016]. New Scientist, (2015). Gene editing saves girl dying from leukaemia in world first. [Online] Available at: https://www.newscientist.com/article/dn28454-gene-editing-saves-life-of-girl-dying-from-leukaemia-in-world-first/ [Accessed 31 Aug. 2016]. Openstax CNX, (2016). DNA Repair. [Online] Available at: https://cnx.org/contents/[emailprotected]/DNA-Repair [Accessed 20 Aug. 2016]. Science Daily, (2015).Potential treatment identified for myotonic muscular dystrophy. [Online]. Available at: https://www.sciencedaily.com/releases/2015/03/150318140652.htm [Accessed 29 Aug. 2016]. Toole,G. and Toole,S. (2015). A Level AQA Biology. 2nd Edition. Glasgow: Bell and Bain Ltd. Pages 36-37, 202-203. University of Rochester Medical Center, (2012). A Promising Step Forward Toward Muscular Dystrophy Treatment. [Online] Available at: https://www.urmc.rochester.edu/news/story/3572/a-promising-step-forward-toward-muscular-dystrophy-treatment.aspx [Accessed 29 Aug. 2016]. Wellcome Trust Sanger Institute, (2001). Ten facts from the Human Genome Project. [Online] Available at: http://www.sanger.ac.uk/news/view/ten-facts-human-genome-project [Accessed 20 Aug. 2016]. Your Genome, (2015). Is germline gene therapy ethical? [Online] Available at: http://www.yourgenome.org/debates/is-germline-gene-therapy-ethical [Accessed 31 Aug. 2016]. Your Genome, (2016). What is CRISPR-Cas9? [Online] Available at: http://www.yourgenome.org/facts/what-is-crispr-cas9 [Accessed 31 Aug. 2016]. Appendices Figues and diagram Figure two Results of muscle weakness in Myotonic Dystrophy patients in contrast to those who dont have the disease. Figure three The stages of using bacteria to edit DNA sequence. Gantt Chart Glossary Deoxyribonucleic acid (DNA) a molecule that is consist of instructions for an organism needs to develop, live and reproduce. Non-overlapping each base in the sequence is read one. Dominant allele the disease is present even if the individual only has one copy of the allele. Ribonucleic acid (RNA) a messenger carrying single stranded instructions from DNA to control protein synthesis. Enzyme-medicated process single enzyme or multiple enzymes synthesis copies of nuclei acid. False positive A result that indicates that a given condition is present when it is not. Cell membrane the partially permeable membrane surrounding the cytoplasm of a cell. Stem cells an undifferentiated cell of a multicellular organism which has the ability to differentiate to repair and replace damaged tissues and organs. Tissue -   group of similar cells working together to perform a special function. Organ Combination of tissues that are coordinated to perfrm a variety of functions. Eg. Heart, lungs. T- Cells Type of lympocyte matured in the thymus gland that is involved in humoral immunity. Enzyme a protein with a specific active site and tertiary structure. It acts as a biological catalyst to bring about a biochemical reaction. Cas9 a protein that guides the RNA to enter cells without undergoing transcription and translation. [DS1]Good start. In future, try to practice academic language. Such as This paper willà ¢Ã¢â€š ¬Ã‚ ¦ or The research in this paper will discussà ¢Ã¢â€š ¬Ã‚ ¦ avoid using I, me, we my etc. [DS2]Good. [DS3]Good [DS4]Excellent points raised. [DS5]Good point

The Dual Nature of Characters in Shakespeares Othello :: GCSE English Literature Coursework

Dual Nature of Characters in Othello  Ã‚   Many of the characters in Shakespeare's tragedy, Othello are duplicitous to the extent that how they are perceived in public is not how they behave in private. The perception of the public plays   a very important role in the play Othello. The character of Iago uses his public perception as an honest man to deceive Othello and other characters in the play. The perception of the public   of Othello and Cassio played an important role in the play. Iago’s public perception played a very key role in the play. Everyone thought of Iago as an honest man. â€Å" O, that’s an honest fellow â€Å" , â€Å"You advise me well ........ goodnight honest Iago â€Å" - â€Å"........that’s an honest fellow â€Å" â€Å" I know thou’rt full of love and honesty †. Iago has everyone fooled into believing that he is a noble honest man. Without this public perception of being honest he could never get Othello to believe that Desdemona was cheating on him. Othello would have probably killed him if he didn’t have the public perception of being an honest man. Iago knew that an important man like Othello couldn’t ignore the possibility that his wife was cheating on him. Nobody suspects that Iago is a deceitful man and would plot and plan to destroy Othello, Cassio and Desdemona in such a cunning way. Iago used his public perception, and the insecurities of Othello being a Moor, to allow him to manipulate Othello. Othello had a public perception of being a military man, and a courageous leader. â€Å"Valiant Othello, We must straight employ you...† â€Å"Here comes Brabantio and the valiant Moor.† Othello has been a soldier since he was seven years of age, and has experience on the battle field. Othello was chosen when they went to fight the Turkish fleet. Because of his public perception, it wasn’t hard for other people to accept the relationship between him and Desdemona. As Iago started putting ideas in Othello’s head about Cassio and Desdemona being together, another side of Othello’s personality started to surface. Because Iago had the public perception of being an honest man, Othello couldn’t ignore his insinuations about Desdemona. Othello wondered if Desdemona really loved him, or if she was just using him to rebel against her father. With Iago constantly putting these ideas in his head, Othello was convinced to kill his wife. Cassio was known to be a good soldier, and is proud of that public perception.

Elvis Essay -- essays research papers

On January 8, 1935 at 4:35 a.m., a little boy by the name of Elvis Aaron Presley was born to parents Vernon Elvis Presley and Gladys Love Presley in a two-room house located in Tupelo, Mississippi. Little did anyone know that this little boy would forever change the world of music and entertainment. Although this was a happy occasion for both of them, it was also a very sad one, too. Elvis had a twin brother, Jesse Garon Presley, who was stillborn just a couple of hours before Elvis himself was born. Elvis was named after his father, Vernon, and Vernon’s best friend, Aaron Kennedy. Elvis’s parents, Vernon and Gladys, married on June 17, 1933. Gladys was 21 and Vernon was only 17. His mother worked as a sewing machine operator while his father was farm hand. When Elvis was 3 years old, his father was convicted of forgery, along with two other men, for a hog they had sold. Vernon was sent to Parchman Prison where he served 9 months. Due to family hardships, Elvis and his family had to move to Memphis, Tennessee. Elvis was raised in a religious home. He grew up surrounded by gospel music. As a boy he sang with his local Assembly of God church choir, which emulated the style of African-American psalm singing. At age ten Elvis placed first in a school singing contest. He then began to teach himself the rudiments of the guitar. In 1949, Elvis was enrolled in the L.C. Humes High School in Memphis. The total combined salary of both his parents was a mere $35 dollars a week, but they managed. In 1953, Elvis graduated from high school and began working as a truck driver while he studied evenings to become an electrician. One day, while driving a truck for his company, Elvis noticed a sign that read, "Memphis Recording Service-Make Your Own Records. Four Dollars for Two Songs." This sign would change his life forever. II. Career Elvis decided he was going to record some songs for his mother as a birthday gift. Upon doing this, he impressed the studio manager with his unique vocal style. He demonstrated outstanding range and influences of African American music. This experience led Elvis to recordings with the studio’s owner, Sam Phillips through his record label, Sun Records. At the age of 21, he recorded his first songs for a major record label, the Radio Corporation of America (RCA). Included in these recordings, wa... ...is is regarded as one of the most important cultural figures of the twentieth century. So many people loved him, and he was an inspiration to many. IV. Comparison to an Important Person Today Elvis Presley was such a unique and influential person that it is hard to compare him to anyone today. In a way, he is in a class of his own. If he were to be compared to anyone in the spotlight today it would probably be someone like Garth Brooks. Garth Brooks is a country singer with thousands of fans around the world. Like Elvis, he has sold millions of records worldwide. Garth is in the music industry just like Elvis was. Although Garth is very popular, he cannot compare to the popularity of Presley. Presley still lives on as a legend today. He starred in 33 major motion pictures, and Garth hasn’t starred in any. It would be impressive to have someone in the spotlight today with the same fame and status as Elvis had. This concludes the story of the most famous and influential person of twentieth century popular culture. His name is Elvis Aaron Presley. His music and fame were, and still are, unprecedented. He is a legend that will forever live on in the hearts of many.

Economics †monopoly Essay

A monopoly is an enterprise that is the only seller of a good or service. In the absence of government intervention, a monopoly is free to set any price it chooses and will usually set the price that yields the largest possible profit. Just being a monopoly need not make an enterprise more profitable than other enterprises that face competiton the market may be so small that it barely supports one enterprise. But if the monopoly is in fact more profitable than competitive enterprises, economists expect that other entrepreneurs will enter the business to capture some of the higher returns. If enough rivals enter, their competition will drive prices down and eliminate monopoly power. Why do economists object to monopoly? The purely â€Å"economic† argument against monopoly is very different from what noneconomists might expect. Successful monopolists charge prices above what they would be with competition so that customers pay more and the monopolists (and perhaps their employees) gain. It may seem strange, but economists see no reason to criticize monopolies simply because they transfer wealth from customers to monopoly producers. That is because economists have no way of knowing who is the more worthy of the two parties—the producer or the customer. Of course, people (including economists) may object to the wealth transfer on other grounds, including moral ones. But the transfer itself does not present an â€Å"economic† problem. Rather, the purely â€Å"economic† case against monopoly is that it reduces aggregate economic welfare (as opposed to simply making some people worse off and others better off by an equal amount). When the monopolist raises prices above the competitive level in order to reap his monopoly. Profits, customers buy less of the product, less is produced, and society as a whole is worse off. In short, monopoly reduces society’s income. The following is a simplified example. Consider the case of a monopolist who produces his product at a fixed cost (where â€Å"cost† includes a competitive rate of return on his) of $5 per unit. The cost is $5 no matter how many units the monopolist makes. The number of units he sells, however, depends on the price he charges. The number of units he sells at a given price depends on the â€Å"demand† schedule shown in Table 1. The monopolist is best off when he limits production to 200 units, which he sells for $7 each. He then earns monopoly profits (what economists call â€Å"economic rent†) of $2 per unit ($7 minus his $5 cost, which, again, includes a competitive rate of return on investment) times 200, or $400 a year. If he makes and sells 300 units at $6 each, he earns a monopoly profit of only $300 ($1 per unit times 300 units). If he makes and sells 420 units at $5 each, he earns no monopoly profit—just a fair return on the capital invested in the business. Thus, the monopolist is $400 richer because of his monopoly position at the $7 price. Table : 1 Price Qty. Demanded Monopoly Profit/Year 7 200 400 6 300 300 5 420 0 The main kind of monopoly that is both persistent and not caused by the government is what economists call a â€Å"natural† monopoly. A natural monopoly comes about due to economies of scale-that is, due to unit costs that fall as a firm’s production increases. When economies of scale are extensive relative to the size of the market, one firm can produce the industry’s whole output at a lower unit cost than two or more firms could. The reason is that multiple firms cannot fully exploit these economies of scale. Many economists believe that the distribution of electric power (but not the production of it) is an example of a natural monopoly. The economies of scale exist because another firm that entered would need to duplicate existing power lines, whereas if only one firm existed, this duplication would not be necessary. And one firm that serves everyone would have a lower cost per customer than two or more firms. Whether, and how, government should regulate monopoly is controversial among economists. Most favour regulation to prevent the natural monopoly from charging a monopoly price. Other economists want no regulation because they believe that even natural monopolies must face some competition (electric utilities must compete with home generation of wind power, for example, and industrial customers can sometimes produce their own power or buy it elsewhere), and they want the natural monopoly to have a strong incentive to cut costs. Besides regulating price, governments usually prevent competing firms from entering an industry that is thought to be a natural monopoly. A firm that wants to compete with the local utility, for example, cannot legally do so. Economists tend to oppose regulating entry. The reason is as follows: If the industry really is a natural monopoly, then preventing new competitors from entering is unnecessary because no competitor would want to enter anyway. If, on the other hand, the industry is not a natural monopoly, then preventing competition is undesirable.

The Emergence Of Professional Identity Education Essay

Despite the outgrowth of professional individuality as a separate research country in the last decennary, there is no individual definition to explicate precisely what the construct means ( Beijaard et al. , 2004 ) . There is common understanding, nevertheless, that individuality is non a fixed property of a individual, but is an on-going procedure of reading and reinterpretation of experiences within a given context. The post-modernist position of ego, to which I subscribe, is that ego is strongly related to how people organise their experiences in their life history, which could, hence, differ in clip and context, but allows persons to understand who they are and what they would wish to go. As a consequence, influences of historical, sociological, psychological and cultural factors may all impact on a leader ‘s sense of ego as a leader. If this line of statement is followed through, it would, hence, seem that ‘self ‘ is inseparable from a individual ‘s life history and, so, it is impossible to talk about ‘self ‘ when there is no contemplation.IntroductionBusher ‘s ( 2005 ) research of in-between leaders highlights how childhood experiences, parents and co-workers shaped his topics ‘ positions and values on instruction, acquisition and taking. He besides found that publicity shaped their sense of work-related individuality, their positions of themselves being bound up with the formal places they held within the school hierarchy. In this manner, professional individualities were developed through a combination of historical life and professional experience. However, it is besides of import to recognize that, when associating this to a life history attack, the narration of events comes to stand for a period of person ‘s lives, compressed into â€Å" one minute of self-narration † ( Kehily, 1995, p. 24 ) . Equally, as Kehily ( 1995 ) argues, how we see ourselves, our individuality, is capable to reformu lation in a assortment of ways harmonizing to the audience and, hence, we may hold a different version of individuality harmonizing to where, when and how we articulate it. Part of our life history can be omitted, embellished or reframed harmonizing to the feeling that we want to portray of ourselves. In other words, individuality is expressed as outward articulations as a merchandise of the societal interaction, instead than an person ‘s interior ideas. As a consequence, a Reconstruction of past events is likely to be placed within the ‘framework of present concerns ‘ ( Kehily, 1995, p. 26 ) . Malus and Wuf ( 1987, in Kehily, 1995 ) use the term â€Å" self construct of the minute † understood as a â€Å" continually active, switching array of accessible ego cognition † ( p. 306 ) . Similarly, single memory plays a big portion in determining and stating their ‘story ‘ . Memory can be selective, go forthing immense spreads and giving minutes of utmost lucidity. Identity building is, hence, an interrelatedness between past and present. Olesen ( 2001 ) , in his survey of professional individuality as acquisition procedures in life history, besides sees individuality as being a â€Å" field for an on-going subjectiveness † ( p. 3 ) . However, instead than it being subjective, harmonizing to the audience as a likely reading, it is more as a consequence of the person ‘s ability to reproduce experience in relation to existent world. It is this world which is capable to single perceptual experience, subjective orientations and significances. He argues that perceptual experience of individuality is besides interrelated to larning procedures of persons within their profession and general development. In this manner, ‘professional ‘ ind ividuality can steer and develop the person but could besides curtail the learning potency. Usher ( 1995 ) believes: â€Å" changing and switching individuality is ‘fixed ‘ and anchored by the act of composing † and that â€Å" life itself is conceived as societal text, a fictional narrative production where difference is repressed and clip suppressed in a demand for certainty † ( p. 2 ) . This position assumes that persons are about incapable of deciding the tenseness between seeing ourselves as the object and how other people influence and nowadays it. Giddens ( 1991 ) argues that how the tensenesss between external and internal positions of ego are resolved depends on single â€Å" histories and experience and societal and psychological demands † ( p. 3 ) . My place in this is that although persons may non be able to decide the tensenesss between external and internal positions, they may travel to a province of cognitive disagreement where they come to accept and recognize the difference without the demand for deciding them.Awareness of O nes SelfBusher ( 2003 ) takes a similar position reasoning that: â€Å" leaders and directors consciousness of ego is constructed through their interactions with other people, developing a altering consciousness of other people ‘s demands and besides of themselves as other people perceive them † ( p. 3 ) . This requires witting contemplation and has been encouraged through the centuries to advance a greater apprehension of the person ‘s sense of ego, the mutuality of people and with their environment ( Busher, 2003 ; Beijaard et al. , 2004 ) . I would besides reason that it besides depends to what extent persons are non merely consciously cognizant of the impact of these interactions, but besides how much they are able to larn from this and, by making so, develop their ain apprehension of people ‘s personal and societal demands, positions and outlooks, in other words, what Goleman ( 1995 ) footings as 'emotional intelligence ‘ . For any ‘people workers ‘ , understanding people ‘s actions in footings of how they construct their self-identity in peculiar contexts is critical to being able to work with them successfully. For leaders at any degree, a sound apprehension of other people is cardinal to success in their function ( Busher, 2005 ) . These soci etal interactions, as Busher ( 2003 ) , argues besides serve to develop impressions of power and that in developing individualities, peculiarly in the work context, people have to â€Å" postulate with the power relationships that operate † ( Smyth et al. , 2000, p. 149 ) . Cardinal to self-identity is besides their impression of power and how it affects their sense of bureau. The grade of authorization and command all physiques upon the individual ‘s sense of ego and is straight related to the place within which they operate and how much power they are able to ordain. Usher ( 1995 ) suggests that, possibly, this atomization of individuality is something we merely necessitate to accept and that it is inevitable â€Å" that the ego will be invented and reinvented † ( p. 186 ) . As can be seen from this treatment, professional individuality and cognition of ‘self ‘ is complex. It is made up of a assortment of elements, grounded in people ‘s single life histories, personalities and work-related experiences. The ability to reflect on their experiences and understand their ain professional individualities allows them to efficaciously wear the mantle of their several ascribed function and to hold a better apprehension of themselves and of those they lead.The Journey to LeadershipWhen analyzing life history, instruction research workers have tended to convey together shared characteristics and anchored them around nucleus subjects ( Gronn, 1999 ) . Both Kelchtermans ( 1993 ) and Parker ( 2002 ) utilize critical incidents, important people and phases as â€Å" heuristic tools in analyzing the calling narratives † ( Kelchtermans, 1993, p. 447 ) , while others ( Day and Bakioglu, 1996 ; Gronn, 1999 ; Coleman, 2002 ; Ribbins, 2003 ) have used phases and stages of leading to develop a conceptual theoretical account of leaders within a â€Å" longitudinal model † ( Gronn, 1999, p. 22 ) .Phases of LeadershipGronn ( 1999 ) termed the first phases of influence on a leader as the â€Å" Formation † phase and this encompasses the period from â€Å" babyhood to maturity † , placing household, schooling and peer mention groups as of import in supplying the â€Å" staging of a character construction † ( p. 32 ) . The 2nd phase, â€Å" Accession † ( Gronn, 1999, p. 34 ) , is the clip of â€Å" training † where persons see a scope of functions, fiting themselves with a assortment of accomplishments and get down to assemble and practise a â€Å" function repertory † ( p. 36 ) which will supply a house foundation upon which to pull for higher functions. It is in this phase, where an person ‘s strong motive to accomplish may foremost be realised, which Gronn ( 1999 ) suggests, to be effectual, needs to be accompanied by a strong sense of single ego belief and the associated feelings of one ‘s â€Å" worth and value † ( p. 36 ) which are developed in the Formation phase. The 3rd phase, that of â€Å" Incumbency † , is about the period of headship. Gronn ( 1999 ) suggests that if, at this phase, the functions that leaders take are â€Å" congruous with personal demands † so they will â€Å" be able to travel some manner to run into their demand to self actualize † ( p. 38 ) . The 4th and concluding phase is that of â€Å" Divestiture † where leaders may good lose their â€Å" psychological clasp † ( p. 39 ) , whether this be due to fortunes impacting on them and hence nonvoluntary or unplanned, or it may be more a voluntary, planned phase of the leader ‘s calling as retirement attacks. Day and Bakioglu ( 1996 ) , in their survey of caput instructors ‘ lives and callings, place a series of developmental stages and sub stages undergone by caputs which are compatible with Gronn ‘s ( 1999 ) model. Their starting point, nevertheless, is at the â€Å" Initiation † phase where caputs are already in function and, hence, could be considered as sub stages or stairss within Gronn ‘s Incumbency phase. Like Gronn ( 1999 ) , Day and Bakioglu ( 1996 ) suggest that there are â€Å" multiple tracts and flights through different stages of caput instructors ‘ lives † ( p. 206 ) . There are four phases of Day and Bakioglu ‘s ( 1996 ) theoretical account: Initiation, Development, Autonomy and Disenchantment. The Initiation phase is characterised by two cardinal procedures: acquisition on the occupation and working within the bing establishment ‘s model. They suggest that idealism, uncertainness and accommodation are three sub stages within this phase. The Initiation phase is followed by a Development stage where consolidation and extension takes topographic point. Day and Bakioglu ( 1996 ) depict this as the â€Å" most active, most satisfactory, most rewarding stage † ( p. 212 ) of the leader ‘s calling and can be compared to the feeling of â€Å" self realization † which Gronn ( 1999, p. 38 ) describes as a possible result of the Incumbency phase. The 3rd stage that Day and Bakioglu ( 1996 ) depict is that of Autonomy, which can be seen as holding both positive and negative effects upon single development and leading effectivit y. In this stage, caputs still have assurance, but their control can be under menace, due to the limitations placed upon them through authorities enterprises and establishment demands, so straight impacting their ability to command their ain sense of bureau. If this deficiency of control persists so much so that they begin to lose a sense of vision, caputs may so come in the 4th stage, that of Disenchantment. Characteristics of this phase include: â€Å" deficiency of assurance, enthusiasm and increasing personal weariness † ( Day & A ; Bakioglu, 1996, p. 224 ) . Ribbins ‘ ( 2003 ) more recent survey confirmed this wide form of calling phases, integrating both Day and Bakioglu ‘s ( 1996 ) four stages and Gronn ‘s ( 1999 ) four phases to suggest a modified model which suggests â€Å" two ideal typical tracts or paths to and through headship † ( Ribbins, 2003, p. 63 ) . Like Gronn ( 1999 ) , Ribbins ( 2003 ) suggests a formation phase where cardinal bureaus impact and determine the sort of people â€Å" that prospective caput instructors become † ( p. 64 ) . Similarly, Ribbins ( 2003 ) describes the 2nd phase of â€Å" Accession † as that clip when persons seek experience and leading functions in readying for future headship places. Ribbins ( 2003 ) notes that, in hindsight, few leaders really see this phase as one of deliberate planning in order to prosecute a class taking to headship. This can be compared to McCall ‘s ( 2000 ) â€Å" serving clip † ( p. 23 ) in order to accomplish their concluding finish. Coleman ( 2002 ) , in her survey of adult females as caput instructors, suggests that there is a â€Å" deficiency of planning and even an component of surprise in happening themselves a caput instructor † ( p. 33 ) and, therefore, the ‘grooming ‘ phase may travel unnoticed by the participant at the c lip. It is in the 3rd phase, that of Incumbency, where Ribbins ( 2003 ) suggests an option to Gronn ‘s ( 1999 ) theoretical account and physiques on Day and Bakioglu ‘s ( 1996 ) four stages. Ribbins ( 2003 ) suggests that leaders can take one of two chief paths at this phase, each of which consists of four bomber stages. The first three bomber stages are the same as Day and Bakioglu ( 1996 ) suggest: Initiation, Development and Autonomy, but with a 4th sub stage of Disenchantment or Enchantment. This is dependent on whether the leader has negative feelings ( disenchantment and loss of committedness ) or positive feelings ( assurance and competency ) at this phase. Whereas Day and Bakioglu ( 1996 ) depict a downwards gyrating procedure taking to disillusionment, or in Gronn ‘s ( 1999 ) term ‘Divestiture ‘ , Ribbins ( 2003 ) suggests that although this disenchantment so may go on, there is besides an option, that of captivation. If this latter stage occurs, the leader will stay enchanted with headship and will go on to be motivated by professional satisfaction, relationships with co-workers and keep a balance between place and school life. The concluding stage, that of ‘Moving on ‘ focal points on go forthing headship. It deals with the way that caput instructors take one time they divest themselves from office. If the caput instructor is able to stay motivated and ‘enchanted ‘ so they can look frontward to reinvention and prosecute a different involvement or business. However, if the caput instructor becomes ‘Disenchanted ‘ they face the chance of Divestiture and, to some, welcome retirement. Coleman ( 2002 ) merges her earlier theoretical account of calling phases ( Hall, 1996 ) with the Van Eck ( 1996 ) theoretical account, to bring forth her version of distinguishable calling phases of caput instructors. She suggests a readying phase where initial makings may be obtained, an establishment phase of come ining instruction and the lower degrees of direction, an promotion or development calling phase affecting deriving new experiences, farther makings and a concluding acquisition phase when headship is achieved. Taysum ( 2004 ) , on the other manus, proposes a model to place the formation of the leaders self. She argues that there are four dimensions which are â€Å" critical to understand how leaders learn † ( p. 10 ) and that it is necessary to travel beyond a additive analysis to one which explores the interplay between â€Å" the exercising of bureau and the construction that form and control that bureau † ( p. 10 ) . In this manner, she argues that leading is deconstructed to give a greater penetration as â€Å" to how leaders learn to go leaders † ( p. 11 ) . Similarly, Johnson ( 2002 ) in her survey of higher instruction leaders, did non mention to phases in leading development but to incremental phases where, over clip, leading becomes more appealing as experience and an increased academic profile rendered them eligible for more senior places. This attack I would reason, is more kindred to Parker ‘s ( 2002 ) and Kelchterman ‘s ( 1993 ) attack of non merely sing life stages but besides other facets such as critical incidents and people. Although Taysum ( 2004 ) affirms this, she besides goes beyond this attack and explores it within an rational, emotional and religious context.Critical IncidentsHarmonizing to Tripp ( 1993 ) , critical incidents in educational research are created and are non something bing independently of an perceiver expecting find. Critical incidents are produced by the manner we look at a state of affairs, an reading of the significance of an event or incident. What makes an incident ‘critical ‘ is that it is memorable and interpreted as important by what it means. Much of the research on life history, which incorporates critical incidents, reaches a similar decision. Gronn ( 1999 ) discusses â€Å" critical turning points † ( p. 28 ) in his stages of leading development. He suggests that they can be in the signifier of impermanent set dorsums which is portion of the class within calling patterned advance. Similarly, Parker ( 2002 ) in his survey of the impact of life history on leading, termed critical incidents as â€Å" specifying minutes † ( p. 25 ) . The importance of these are illustrated in his concluding comments about the caput instructors in his survey, where he suggests that such experience â€Å" helped them specify their educational doctrines and hone their accomplishments † ( p. 25 ) and so believed much of their life history influenced their leading manner. These specifying minutes were seen as â€Å" motivational drivers † ( p. 33 ) which: â€Å" created the deep-rooted sense of career that these caputs have carried with them throughout their callings † ( p. 34 ) . Goodson and Walker ( 1991 ) reached a similar decision when analyzing the life history of instructors reasoning, that critical incidents in: â€Å" instructors ‘ lives and specifically in their work which may crucially impact perceptual experience and pattern † ( p. 24 ) . Knight and Trowler ‘s ( 2001 ) reappraisal of the functions of leader-academics in higher instruction argue that they need seven types of cognition and propose some ways in which leaders might develop them. Reviewing critical incidents and important friends are some of the ways they suggest to develop and prolong the first signifier of cognition in their list, that of ‘control cognition ‘ ( p. 168 ) . Contemplation on incidents is, hence, required if some experiences are to go ‘critical incidents ‘ . The survey of life history allows this contemplation to take topographic point and the building of their ain perceptual experiences of personal experience and therefore the significance these experiences have on the respondent. Harmonizing to Angelides ( 2001 ) , it is besides an efficient technique of garnering qualitative informations because a big sum of qualitative informations can be collected covering a broad clip span.Significant PeoplesThere is general understanding within the literature that critical people are â€Å" strategically located forces † who â€Å" contribute to the manner and velocity of calling promotion † ( Gronn, 1999, p. 28 ) . Dhunpath ( 2000 ) discusses how the â€Å" interpersonal context † depicting critical people as â€Å" important others † such as parents, wise mans, co-workers and equals as: â€Å" both powerful positive and negative influences that shape an pedagogue ‘s pattern † ( p. 546 ) . Similarly, Parker ( 2002 ) besides discusses the importance of wise mans who were responsible for determining the thought of those leaders that he studied â€Å" at intensely formative minutes of their lives † and goes on to state they â€Å" were important to fixing these caputs for leading functions † ( p. 35 ) . Ribbins ( 2003 ) reiterates this importance at the formative phase and believes that they are partially responsible for act uponing and determining â€Å" the sorts of people that prospective caput instructors become † ( p. 63 ) . Coleman ( 2002 ) suggests that the significance of critical people is peculiarly of import for female leaders, as they bes ides provide function theoretical accounts for them. One of her respondents illustrates this by stating that the critical individual for her was a caput that: â€Å" encouraged me to travel for headship and likely more than any other individual in my calling † ( p. 26 ) . Kelchterman ( 1993 ) finds the usage of critical people every bit good as incidents and phases as â€Å" really utile heuristic tools in researching the calling narratives † ( p. 446 ) but besides every bit theoretical constructs. He uses both constructs to exemplify the influence they have on the professional committedness and occupation satisfaction of the instructors in his survey, both in a positive and negative manner. It besides proves utile in â€Å" retracing the ( development of ) the professional ego from the calling narratives † ( p. 448 ) . In the latter phases of their calling and, peculiarly, for more senior leading functions, Johnson ( 2002 ) found that leader-academics ‘ contact with experts in their field was of great aid in larning how to take. These people became important in determining and developing their leading capableness, peculiarly in the absence of any formal preparation or development.Professional Development and Training for LeadershipThe increasing accent on ‘managerialism ‘ in which instruction establishments are given greater liberty, are exposed to market force per unit areas and are expected to pull off uninterrupted betterment in their public presentation, places an accent on the importance of leading and the direction of instruction alteration. Equally, the scope of duties attributed to the leader-academic function demonstrates how much leaders need to larn in order to take. The volatility of the higher instruction clime besides adds a farther bed to the demand for larning, dev elopment and support for the leader-academic. Despite this, there is a surprising deficit of research or books on professional development for middle-level leader-academics. Those which do cover different leading activities ( for illustration: Bolton, 2000 ; Smith, 2002, 2005 ; Prichard, 2000 ) tend to handle leading as a generic activity, with inside informations of what leaders do instead than how they should develop in order to larn to take, although Smith ( 2007 ) does get down to turn to this in his most recent work. Possibly it is even more surprising that many universities provide small or no formal preparation ( Johnson, 2002 ; Smith, 2005 ) . A common trouble identified by many new leader-academics in Smith ‘s ( 2007 ) research is that the bulk lacked readiness for the function and had received no leading or direction preparation before and following their assignment. The preparation that did be tended to be on issues related to wellness and safety, equality and dispo sal systems instead than specifically leading development. This determination may explicate why few in the survey by Rhodes et Al. ( 2007 ) held impressions of professional development as an bureau of motive or satisfaction. Similarly, Aziz et Al. ( 2005 ) lament the deficiency of developing â€Å" despite it being an issue that has been discussed by research workers for over 30 old ages † ( p. 573 ) . This is in blunt contrast to the increasing national accent placed on leading development at school and farther instruction degree ( James and Vince, 2001 ) . For illustration, leading characteristics conspicuously in school reviews ( Office for Standards in Education: OFSTED ) , it has an of import focal point in the examination of local instruction authorization ( LEA ) monitoring and reappraisal ( Teacher Training Agency, 1998 ) ( TTA ) ; a leading college for schools has been established and a national professional making for caput instructors ( NPQH ) has been developed. F urther to these enterprises, plans have besides been designed to back up and develop caput instructors who are both new to the station and for longer functioning caput instructors. Similarly, in farther instruction, ‘The Centre for Excellence in Leadership ‘ ( CEL ) has been established since 2003 to â€Å" guarantee first leading within the acquisition and accomplishments sector † ( www.lums.lancs.ac.uk/leadership/cel ) . While it is recognized that the ‘Leadership Foundation for Higher Education ‘ has been established more late to foreground the importance of leading development within higher instruction, nationally the focal point appears to be much lower key than in the school and FE sectors. Arguably, leaders in higher instruction are capable to equal alteration as that in the school and farther educational sectors and so the importance of effectual leading is as of import. However, due to the complexnesss of leading at section and module degree which have developed since the 1992 Education Reform Act, it would look that larning to take demands to be far more made-to-order and contextualised for each leader and within single modules and universities. Blackmore and Blackwell ( 2006 ) concur with this position, reasoning that a generic attack which assumes that leaders all have the same concerns and motives and that these are unchanging, is improbable to be successful. It is likely that leader ‘s clip will be dominated by undertakings that are rather different from the involvement in research or instruction that vivified their callings to day of the month ( Knight and Trowler, 2001 ) . As a effect, Knight and Trowler ( 2001 ) argue that larning to take should include acknowledgment that the leading function has the possible to: â€Å" gnaw the ego individuality that has brought calling success † ( p. 166 ) . They besides suggest that portion of larning to take will affect being more stray, to set the involvements of the establishment as high or higher than their module or squad. As a effect, it may besides affect being criticized for the determinations that they will hold to do. Keeping up with the demands and wants of the university ‘s clients and pull offing the relationships with the external universe is of all time more demanding for the leader-academic. As collegiality still operates to some extent, deriving general consent for the manner forward is more hard even though it is still seen as a: â€Å" critical portion of the in-between director ‘s occupation in higher instruction to derive the co-operation of staff † ( Hellawell and Hancock, 2001, p. 195 ) . Aziz et Al. ( 2005 ) note that, although surveies allow some sense of the duties of the leader-academic, there appears to be no consensus bing as to which dimensions are most of import or around which dimension preparation plans should be designed. To travel portion manner in rectifying this, their survey inside informations the design, execution and findings from a formal procedure of measuring the preparation demands of the leader-academic within one American university. Although they do this for merely one university, the theoretical account is utile in that it could be built upon and tailored to other universities. However, whichever theoretical account to which one subscribes, it is evident that contextual acquisition is traveling to be of import for leaders. It would be logical to presume that this â€Å" contextual acquisition † ( Hellawell and Hancock, 2001 ) can merely be achieved by being exposed to leading responsibilities earlier on in their calling ; therefore they have a better apprehension of the function of leading before they are appointed ( in the instance of the statutory university ) or have it imposed on them ( in the instance of the hired university ) . While it is comparatively straightforward to learn procedure and cognition of leading, as evidenced by the figure of generic classs ( e.g. hypertext transfer protocol: //www.Leadership-he.com/programmes ) and texts ( e.g. Bolton, 2000 ) available in these countries, it would look that situational cognition is as of import but more hard to learn. Knight and Trowler ( 2001 ) list the seven types of leading and direction co gnition that they believe leader-academics should derive. These include the followers: Control cognition Knowledge of people Knowledge of educational pattern Conceptual cognition ( cognizing about direction and leading constructs and research ) Procedure cognition ( procedures of leading and direction ) Situational cognition ( understanding eventualities that have made the module what it is and impact what it might be ) Tacit cognition that integrates the other six signifiers in adept pattern Adapted from Knight and Trowler ( 2001, p. 168 ) . This provides a utile model from which leaders can get down to set up what they need to larn in order to take efficaciously. However, while experience is a widely regarded method of larning and development, Johnson ( 2002 ) points out that persons must be aware that bing cognition, accomplishments and patterns are rapidly outdated and as new jobs and restraints emerge, new signifiers of expertness are needed. This type of informal acquisition is likely to be unstructured, ill-defined, unplanned and it is, hence, doubtful how much development really takes topographic point. Such experiential acquisition can non be merely an sum of clip spent but knowledge demands to be gained through the active reading of experience by the scholar ( Burgoyne and Stuart, 1991 ) . What Johnson ( 2002 ) found peculiarly worrying in her survey of leader faculty members was their inability to joint what they had learnt and how it had come approximately. Lessons learnt remained tacit cognition which could be particularly debatable if there was the demand to rethink their attacks and patterns. I would propose more good to development is ‘Integrated managerial ‘ acquisition ( Mumford, 2004 ) which still occurs within managerial activities but there are clear development aims identified and the development is planned and reviewed. This is because research indicates effectual acquisition is embodied in the ‘doing ‘ ( Sugrue, 2002 ) . Critical contemplation is an of import constituent of this procedure if the experience is to take on peculiar significance. In this manner, acquisition is existent, direct, witting and likely more significant than by the inadvertent method of informal, unplanned acquisition. However, the challenge here is to convey informal procedures of larning in to the development of leaders in maintaining with leaders preferable ways of larning. Blackmore and Blackwell ( 2006 ) take a similar position proposing leader-academics need support to larn on the occupation through mentoring, brooding appraising reappraisal and planning which allows acquisition and tacit cognition to be identified, shared and extended. Indeed, Muijs et Al. ( 2006 ) , when looking at leading development in extremely effectual farther instruction suppliers, discourse the sensed effectivity of experiential signifiers of professional development which build on the leader ‘s background and demands. They peculiarly advocate encompassing technological developments which allow cost effectivity and consideration of development chances for the person. The duality of leading acquisition in situ is that, although it becomes a merchandise of pattern and is gradual over clip to let in-depth apprehension of academic civilization and work, there remains the potency that when leader-academics take on leading functions there is still a steep initial larning curve ( Johnson 2002 ) . It would, hence, seem that larning to take comes from a scope of beginnings. Given the current volatility and alteration in higher instruction, preparation and support should be made available in the signifier of advice, chances for structured single contemplation and regular formal and informal interaction with their equal group. Those who are non as successful at larning to take may get by and trust on their positional authorization to accomplish conformity. Those who can larn from the broad spectrum of beginnings should make more than header and, alternatively, be leaders of successful modules.DrumheadIt would look that research workers are in wide understan ding that leaders, surely within the mandatory instruction sector, do travel through distinguishable life phases and that critical incidents and important people do hold an impact on how leaders learn to take. As can be seen from this treatment, while leading and development has become one of the chief subjects of national instruction direction at school degree, small has been done to back up the development of leaders within higher instruction. There are a figure of ways in which development can be implemented, both officially and informally, to help leaders in their function. However, it has besides been seen that the accomplishments and cognition for effectual leading develop over clip and through sing a assortment of functions on the path up to a leading place. Given the importance attached to leading within instruction, guaranting a supply of able center and senior leaders is critical to single educational institutional success. As a consequence, such organisations need to ship on systematic sequence planning to guarantee there is a supply of able leaders non merely to carry through those going but besides to develop leading at all degrees throughout the organisation, non needfully me rely for make fulling specific stations.